HNF4A and hepatocellular carcinoma: We also performed ChIP-qPCR using the primers designed for the −1482 to −1296 region of the circ_104075 promoter in clinical HCC tissues; the results demonstrated that the circ_104075 promoter (−1482 to −1296 region) was combined with HNF4a in HCC tissues to a greater extent compared to that in the adjacent normal tissues (Fig. 3c).