SOD1 and hydrops fetalis: We can hypothesize that iron supplementation, through increased antioxidant defenses or improvement of mitochondrial function, could reduced this detrimental oxidative stress, although this mechanism is unlikely to contribute to beneficial effects of iron supplementation in our model since we did not find evidence of increased oxidative stress, however increased SOD activity both in Sh and HF rats receiving iron in our model is intriguing here.