Humans carrying mutant alleles of the lipolytic coactivator α/β-hydrolase domain-containing 5 (ABHD5), also designated as comparative gene identification 58, develop neutral lipid storage disease with ichthyosis [NLSDI; also referred to as Chanarin-Dorfman syndrome (OMIM: 275630)] (15, 16). The gene discussed is ABHD5; the disease is ichthyosis.