ABHD5 and Dorfman-Chanarin disease: Humans carrying mutant alleles of the lipolytic coactivator α/β-hydrolase domain-containing 5 (ABHD5), also designated as comparative gene identification 58, develop neutral lipid storage disease with ichthyosis [NLSDI; also referred to as Chanarin-Dorfman syndrome (OMIM: 275630)] (15, 16).