To assess whether EGFR signaling is required for c‐Fos‐dependent bone tumors, we genetically attenuated EGFR signaling by breeding H2‐c‐fosLTR mice to mice carrying the hypomorphic Egfr waved‐2 allele (Egfrwa2/wa2), leading to reduced EGFR activation (Luetteke et al, 1994). This evidence concerns the gene EGFR and bone neoplasm.