PTEN and Intellectual disability: Heterozygous germline PTEN mutations are associated with diverse clinical outcomes, including several tumor predisposition phenotypes (collectively called PTEN harmatoma tumor syndrome), intellectual disability and autism spectrum disorders (Hobert et al., 2014; Li et al., 1997; Liaw et al., 1997; McBride et al., 2010; O'Roak et al., 2012; Orrico et al., 2009; Sanders et al., 2015; Varga et al., 2009).