Since its characterization, the significant transcription of TFR2 gene appeared evident in BM cancer cells, in particular, erythroid leukemic cells [5], but also in myeloid malignant cells [2], while Tfr2β seemed much more prevalent than the TfR2α isoform in chronic B cells lymphocytic leukemia (B-CLL) cells [102]. Here, TFR2 is linked to B-cell chronic lymphocytic leukemia.