Because Nav1.5 interacts with dystrophin [34] and other protein members of the DAPC, the syntrophins [28,29,34], it is conceivable that the disturbance of these interactions, in the case of dystrophin deficiency, impairs Nav1.5 expression and localization. The gene discussed is SCN5A; the disease is neuromuscular disease caused by qualitative or quantitative defects of dystrophin.