Because Nav1.5 interacts with dystrophin [34] and other protein members of the DAPC, the syntrophins [28,29,34], it is conceivable that the disturbance of these interactions, in the case of dystrophin deficiency, impairs Nav1.5 expression and localization. This evidence concerns the gene DMD and neuromuscular disease caused by qualitative or quantitative defects of dystrophin.