For example, miR-199a-3p has been mentioned to play an antitumor role in HCC through targeting c-MET, VEGFA, VEGFR1, VEGFR2, and MMP2. Consistently, miR-199a-3p may inhibit the proliferation of HCC cells via targeting c-MET and antagonizing downstream signals STAT3, mTOR, and ERK1/2 [107]. This evidence concerns the gene MMP2 and hepatocellular carcinoma.