Based on the importance of NCOA4 in erythropoiesis and systemic iron homeostasis, future studies of NCOA4 function in the context of anemia and hemochromatosis and whether inhibition or upregulation of ferritinophagy can impact these and other disease processes where iron homeostasis is dysregulated will be informative. The gene discussed is NCOA4; the disease is anemia (phenotype).