Similarly, in a mouse model of melanoma, intratumoral injection of functionalized mesoporous silica-based microparticles (with pore size up to 30 nm in diameter), that allowed for sustained release of anti-CTLA-4 antibody, slowed tumor growth (p < 0.05), and improved survival, compared to systemic administration of CTLA-4 blocking antibody or IgG conjugated microparticles [117]. This evidence concerns the gene CTLA4 and neoplasm.