Similarly, in medulloblastoma, the role of AMPK as both an inhibitor of GLI1 and SHH signaling [28,29,30,33] (tumor-suppressive effect) as well as a promoter of CNBP and polyamine metabolism (pro-tumorigenic effect) supposes a dual role for AMPK in this disease context. The gene discussed is SHH; the disease is medulloblastoma.