In agreement with an AMPKα2-specific function in SHH medulloblastoma and the fact that the cerebellar granular neuron progenitor cell (CGNP) is the “cell of origin” in SHH-driven medulloblastoma [53], AMPKα2 is expressed at higher level than AMPKα1 in cerebellar granule neurons [54]. This evidence concerns the gene PRKAA1 and medulloblastoma.