NLRP3 and peripheral arterial disease: There is a connection between some inflammatory disease and thrombosis, showing an increase of prothrombotic molecules and platelet activation [73], diverse atherothrombotic diseases such as acute coronary syndrome, stroke, or peripheral arterial disease are caused by the rupture of an atherosclerotic plaque., The platelet NLRP3 inflammasome promotes secretion of IL-1β, using a direct NLRP3 inhibitor there is a reduction of human platelet aggregation [74].