In contrast, the miR-130b down-regulation in hepatoma samples increased the THRA1 and interferon regulatory factor 1 (IRF1) gene expressions, as well as EMT-related genes, the phosphorylation of MTOR, and the STAT3 and AKT activation-pathways that increase the motility and invasion of hepatoma cells [89]. The gene discussed is IRF1; the disease is hepatocellular carcinoma.