Consistently, Tu et al. later found 6 aberrantly methylated genes with differential expression in thyroid cancer: peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), CREB binding protein (CREBBP), p300, CD44 antigen homing function and Indian blood group system (CD44), secreted phosphoprotein 1 (SPP1), and matrix metallopeptidase 9 (MMP9) [57]. The gene discussed is SPP1; the disease is thyroid gland carcinoma.