Thus, c-Kit activity probably leads to the phosphorylation of tyrosine 158 residue and FLT3 mediated Lyn activation leads to phosphorylation of tyrosine 176 residue preventing PTPIP51 to bind 14-3-3β and in consequence modulating the MAPK activity in AML blasts. Here, FLT3 is linked to acute myeloid leukemia.