The examination of the aforementioned cellular signaling and many more, e.g., platelet-derived growth factor receptor (PDGFR) signaling, neurofibromatosis type 1 (NF1) and the tumor microenvironment, lead to crucial insights in the aberrant tumor signaling, but up to now a linkage between these structures is still missing. This evidence concerns the gene PDGFRB and neoplasm.