In addition, as indicated by the interaction profile of PTPIP51 and PKA, serine 212 phosphorylation which enhances the interaction of PTPIP51 and Raf, is much more reduced in dysplastic nevi and to a lesser degree in malignant melanoma cells as indicated by their lower interaction levels of PTPIP51/PKA in comparison to an almost doubled interaction seen in normal melanocytes. This evidence concerns the gene RMDN3 and melanoma.