Importantly, in this study, the authors demonstrate that infection with a miR-US5-1/miR-UL112-3p double mutant virus resulted in increased IKKα and IKKβ protein levels and increased proinflammatory cytokine secretion in human fibroblasts, endothelial cells, as well as in THP-1 cells. The gene discussed is IKBKB; the disease is infection.