ADIPOQ and prediabetes syndrome: Several reasons could explain this observation; (i) rs266729 may not have a direct effect on adiponectin expression/activity in contrast to rs1501299, (ii) the effect of rs1501299 on prediabetes could be specifically modified by the presence of other SNPs in the vicinity of the same genomic area, and (iii) the effect of rs266729 may be small and would thus require a more highly powered study design to detect an association.