RUNX3 and colorectal carcinoma: To assess CRC CIMP, Weisenberger et al. developed a marker panel of five genes (calcium voltage-gated channel subunit alpha1 G, CACNA1G; insulin-like growth factor-2, IGF2; neurogenin-1, NEUROG1; runt-related transcription factor 3, RUNX3; and suppressor of cytokine signaling 1, SOCS1) [21].