Five aberrantly methylated genes (epidermal growth factor, EGF; carbohydrate sulfotransferase 10, CHST10; ependymin related 1, EPDR1; bone marrow stromal antigen 2, BST2; and Rac family small GTPase 3, RAC3) were further verified in CRC tumor tissues. Here, RAC3 is linked to neoplasm.