CDKN2A and colorectal carcinoma: To date, hypermethylation of the promoter of several genes, including APC, p16INK4a, tissue inhibitor of metallopeptidase-3 (TIMP3), twist-related protein 1 (TWIST1), and growth arrest-specific 7 (GAS7), has been reported in CRC [25,26], and several DNA methylation markers have been proposed as useful early biomarkers to detect CRC [27,28,29].