The FOXF1 locus at human chromosome 16q24.1 is deleted in prostate cancer, whereas the FOXA1 gene at human chromosome 14q21.1 is amplified in various different cancers such as anaplastic thyroid cancer, estrogen receptor-positive breast cancer, esophageal cancer, lung cancer or metastatic prostate cancer [17]. Here, FOXA1 is linked to Familial prostate cancer.