In contrast, both B- and T-cell immune responses to other tested antigens, such as early secretary antigen target with 6 kDa (ESAT6), culture filtrate protein 10 kDa (CFP10) [17], and alpha-crystalline-like protein (Acr or HspX)[18] are higher in active tuberculosis patients than in patients with LTBI or past tuberculosis[15, 16]. This evidence concerns the gene ACR and tuberculosis.