However, it has also been found that promoter hypermethylation mediated silencing or low expression of UCHL1 were also found in multiple tumors, including ovarian [15], nasopharyngeal [16], gastric [17], prostate [18], esophageal [19], hepatocellular [20] and breast [21] cancers, indicating UCHL1 as a tumor suppressor. The gene discussed is UCHL1; the disease is cancer.