However, the combinational therapy significantly enhanced the absolute amount of CD8+ TILs in the tumor microenvironment compared to anti-CD25 monotherapy (11.3 vs. 6.5, p = 0.011), anti-TGF-β monotherapy (11.3 vs. 5.0, p = 0.002) and control group (11.3 vs. 5.9, p = 0.004). The gene discussed is CD8A; the disease is neoplasm.