TGFB1 and neoplasm: We found that in comparison to the PBS control group, changes of tumor volume on day 7 (p = 0.001), day 14 (p = 0.002), day 21 (p = 0.028), day 28 (p = 0.035) and day 35 (p = 0.008) with the combination therapy of anti-CD25 antibodies and anti-TGF-β antibodies were all significantly different (Additional file 2: Figure S1A).