PHGDH and cancer: Using transcriptome profiling and pathway analysis after FBXO17 knockdown, CKS1B and SKP2 were notable genes that were differentially expressed and important in regulating cell cycle progression through Skp2-mediated degradation of the tumor suppressor p27Kip [38, 39] Other genes were affected including genes important in metabolism such as PHGDH, RIOX2, and KLF4 that have been shown to have pleotropic roles in chemotherapeutic resistance in different cancers [40–42].