When we examined pathways affected by knockdown of FBXO17 using RNA microarray analysis, we identified enrichment of genes affected which included endopeptidase proteins and pathways, hypoxia-inducible factor 1-alpha (HIF1α) pathway genes, and both squamous cell cancer and adenocarcinoma-associated genes (Fig. 4c-f). Here, HIF1A is linked to squamous cell carcinoma.