Our univariate analysis of possible risk factors revealed that BM plasma cells ≥5%, ISS stage III, age ≥60 years, beta‐2‐MG>5.5 mg/L, creatinine>176.8 μmol/L, CD117 negativity, and CD81 positivity could each affect the survival of PCM patients. Here, CD81 is linked to paracoccidioidomycosis.