In the entire cerebrum, structural connectivity correlated with tau deposition (Figure 8) and demonstrated increased connectivity of the CC, IOF, cingulum, CST, ML, and SCP/MCP (FDR = 0.0033) in the CN group, but with decreased connectivity of the IOF, CST, and MCP (FDR = 0.0129) in the AD‐spectrum group. Here, MAPT is linked to Alzheimer disease.