Recently, Duan et al and Lu reported that the expression of GPC1 was significantly higher in PDAC than in normal pancreatic tissues and that the higher GPC1 expression in PDAC tissues correlated to poor survival.29, 30 Whether serum GPC1 level was an independent prognosis factor in PC patients remains to be determined. The gene discussed is GPC1; the disease is pachyonychia congenita.