Osteoporosis may rarely occur as a monogenic condition, e.g. X‐linked osteoporosis due to mutations of the Plastin 3 (PLS3) gene 18, or early‐onset osteoporosis due to heterozygous mutations of the Wnt family member 1 (WNT1) gene (Table 1) 19. Here, PLS3 is linked to osteoporosis.