For example, Cbx7 has been identified to act as tumor suppressor in lung carcinoma by suppressing CCNE1 expression (Forzati et al., 2012); conversely, it has been shown to act as an oncogene in gastric cancer by repressing p16 (INK4a) (Zhang et al., 2010). The gene discussed is CDKN2A; the disease is lung carcinoma.