Attenuation of IFNγ-induced PD-L1 expression in melanoma cells was proven to happen via down-regulation of the Jak/STAT/IRF-1 signaling pathway (67, 68), while activation of Jaks led to PD-L1 up-regulation in hematopoietic tumor cell lines and primary tumor cells (69). The gene discussed is SOAT1; the disease is neoplasm.