PPARGC1A and Duchenne muscular dystrophy: To extend these findings, the overexpression of PGC-1α or PGC-1β in mouse skeletal muscle was found protective against muscle mass loss following denervation, fasting, and hindlimb unloading (Sandri et al., 2006; Brault et al., 2010; Cannavino et al., 2014, 2015) and in a model of Duchenne muscular dystrophy (DMD; Handschin et al., 2007; Selsby et al., 2012).