APP and neuroblastoma: To optimize the non-toxic dose of WA, different concentrations of WA (0.5–10 μM) were treated to SH-APP (neuroblastoma cell lines stably expressing human APP751) cells and results showed that 2 μM of WA reduces the secreted Aβ40 in SH-APP cells significantly when compared to non-treated control, (Figure 1A) without inducing cytotoxicity to the cells (Figure 1B).