PGAM1 and neoplasm: Although less consistently than SIRT4, SIRT1 was also associated with tumour suppressor function in cellular metabolic regulation (Chalkiadaki and Guarente, 2015), repressing glycolytic metabolism, indirectly through HIF1α deacetylation and directly by inhibiting the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) through deacetylation (Lim et al., 2010).