Additionally, KDM4C overexpression in breast cancer is associated with increased glycolytic metabolism through HIF-1α interaction (Luo et al., 2012) and LSD1 is implicated in gluconeogenesis inhibition through H3K4me2 demethylation, leading to FBP1 and G6P transcription repression (Pan et al., 2013) and favoring HIF-1α-dependent glycolytic metabolism, in hepatocellular carcinoma (Sakamoto et al., 2015). This evidence concerns the gene HIF1A and hepatocellular carcinoma.