Accordingly, SIRT6 deletion, observed in different tumours, like colon, pancreatic and hepatocellular carcinomas, leads to increased H3K9ac levels resulting in glycolytic gene expression upregulation promoting cellular transformation and, consequently tumour growth and progression (Sebastian et al., 2012; Chalkiadaki and Guarente, 2015). The gene discussed is SIRT6; the disease is neoplasm.