In parallel to intra-tumor T cell and immunosuppressive cell quantifications, we used our mouse models of combination regimens to investigate the expression of T cell exhaustion markers such as the T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), the Lymphocyte-activation gene 3 (LAG3) and the T cell immunoreceptor with Ig and ITIM domains (TIGIT). This evidence concerns the gene TIGIT and neoplasm.