SHANK3 and brain disorder: A number of Shank3-mutant mouse lines have been generated and characterized in an effort to understand the in vivo functions of Shank3 and identify important mechanisms underlying Shank3-related brain disorders (Bozdagi et al., 2010; Peca et al., 2011; Wang et al., 2011; Schmeisser et al., 2012; Yang et al., 2012; Han et al., 2013; Kouser et al., 2013; Lee et al., 2015; Speed et al., 2015; Jaramillo et al., 2016; Mei et al., 2016; Wang et al., 2016; Zhou et al., 2016; Jaramillo et al., 2017; Vicidomini et al., 2017; Bey et al., 2018; Qin et al., 2018).