These results indicate that two different global Shank3 deletions (exons 14–16 and 4–22) in mice lead to remarkably similar behavioral phenotypes in mice in social, repetitive, locomotor and anxiety-like behavioral domains, but that these similarities are minimized by two different cKOs restricted to GABAergic neurons (Dlx5/6 and Viaat). The gene discussed is SHANK3; the disease is Anxiety.