SHANK3 and psychiatric disorder: In further support of the importance of Shank3 expression in GABAergic neurons, Shank3 is highly expressed in the striatum (Peca et al., 2011), a brain region enriched with GABAergic neurons and known to be associated with various brain functions as well as neurological and psychiatric disorders (Balleine et al., 2007; Kreitzer and Malenka, 2008; Grueter et al., 2012; Báez-Mendoza and Schultz, 2013).