Microgliosis in AD is evidenced both microscopically and biochemically with increased levels of the proinflammatory cytokines including tumor necrosis factor-α (TNFα), IL-6, and IL-1β (Itagaki et al., 1989; Dickson et al., 1993; Ferretti and Cuello, 2011; Eikelenboom et al., 2012; Latta et al., 2014). Here, TNF is linked to Alzheimer disease.