Reflecting the association between emm type and infection and the high correlation between emm typing and SAg profiling (Friães et al., 2013a), SAg profiles 8 and 10, which correspond mostly to emm3 and emm1, respectively, were associated with iGAS (p = 0.001 and p < 0.001, respectively), (Supplementary Figure 4B). This evidence concerns the gene PIGG and infection.