These findings suggest that STZ-induced hyperglycemia increased plaque thrombosis and myocardial infarction independently of alterations in atherosclerosis development in coronary arteries and suggest that HFC diet fed SR-B1-KO/hypoE mice may be a useful non-surgical model for hyperglycemia-induced plaque thrombosis and myocardial infarction. The gene discussed is SCARB1; the disease is myocardial infarction.