LDLR and Hyperglycemia: However, the effects of hyperglycemia on coronary artery atherosclerosis are less well-studied, in part because conventional mouse atherosclerosis models, such as apolipoprotein E (apoE) or LDLR deficient mice, do not develop substantial coronary artery atherosclerosis or subsequent myocardial infarction (Gonzalez et al., 2016; Trigatti and Fuller, 2016).