POSTN and fibrosis: Consistent with increased fibrosis, they exhibited increased abundance of periostin (Figures 5F–I), a transforming growth factor β-inducible matricellular protein known to play an important role in cardiac fibrosis and induced post-myocardial infarction and in diabetic cardiomyopathy (Frangogiannis, 2012; Guan et al., 2015; Landry et al., 2018).