The similarity in phenotypes (increased coronary artery disease, myocardial infarction, and reduced survival) across two different mouse models and modes of hyperglycemia induction (high fat diet fed Ins2-akita/apoE KO mice in Venegas-Pino et al., 2018 and HFC diet fed, STZ-treated SR-B1-KO/hypoE mice in this study) suggest that these effects are likely driven by the hyperglycemia. This evidence concerns the gene APOE and Hyperglycemia.