SR-B1 KO mice homozygous for a hypomorphic mutant apoE allele (hypoE) also develop HFC diet-induced coronary artery atherosclerosis, myocardial infarction, cardiac dysfunction, and reduced survival (Zhang et al., 2005; Nakagawa-Toyama et al., 2012; Hermann et al., 2016; Luk et al., 2016). The gene discussed is APOE; the disease is coronary atherosclerosis.