On the other hand, it was recently reported that genetic induction of hyperglycemia (due to mutation of the insulin2 gene) in male apoE-KO mice resulted in coronary artery atherosclerosis, myocardial fibrosis, and reduced survival upon feeding a high fat, atherogenic diet (Venegas-Pino et al., 2018). Here, APOE is linked to coronary atherosclerosis.