Hyperglycemia is a risk factor for atherosclerotic disease in humans (Harrington et al., 2010; Secrest et al., 2010; de Ferranti et al., 2014), and has been shown to accelerate either spontaneous (apoE-KO mice), or diet-induced atherosclerosis (both apoE-KO and LDLR-KO mice) (Park et al., 1998; Vikramadithyan et al., 2005; Werstuck et al., 2006; Johnson et al., 2011; Veerman et al., 2013; Venegas-Pino et al., 2013; Al-Sharea et al., 2018). Here, APOE is linked to Hyperglycemia.