APOE and atherosclerosis: This is surprising given the literature that demonstrates that STZ-treatment generally increases spontaneous and high fat diet-induced atherosclerosis in apoE-KO and/or LDLR-KO mice (Park et al., 1998; Vikramadithyan et al., 2005; Werstuck et al., 2006; Johnson et al., 2011; Veerman et al., 2013; Venegas-Pino et al., 2013; Al-Sharea et al., 2018).