Mice deficient in both SR-B1 and apo E, SR-B1/apoE double KO mice, exhibit accelerated aortic sinus atherosclerosis development (Trigatti et al., 1999) as well as spontaneous development of extensive, occlusive atherosclerosis in coronary arteries, myocardial infarction, and early death (∼6–8 weeks of age; Braun et al., 2002). Here, SCARB1 is linked to myocardial infarction.