The early death of SR-B1-KO/hypoE mice fed atherogenic HFC diets and of related SR-B1/apoE double KO mice fed normal chow diets has been attributed to their striking cardiovascular phenotypes of coronary artery atherosclerosis and myocardial infarction, which are accompanied by cardiac conductance abnormalities and reduced left ventricular function (Braun et al., 2002, 2003; Karackattu et al., 2006; Al-Jarallah et al., 2013; Hermann et al., 2016; Luk et al., 2016; Liao et al., 2017). This evidence concerns the gene APOE and coronary atherosclerosis.