Our observations that STZ-treatment increased HFC diet induced coronary artery atherothrombosis, myocardial infarction, and early death of SR-B1-KO/apoE-hypo mice suggests that this may be a useful model to study the effects of hyperglycemia on diabetic cardiomyopathy that does not require surgical ligation of coronary arteries. Here, SCARB1 is linked to diabetic cardiomyopathy.