Obesity and T2DM are associated with a low chronic subclinical inflammatory state, which is mediated by inflammatory mediators (e.g., TNFα, IL-6, iNOS, and C-reactive protein) produced by adipose tissue (20–23), macrophage infiltration, and insulin insensitivity in adipose tissue (18). This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.