Indeed, in the hippocampus there is a dense expression of glucocorticoid receptors (GR), and it is thought that the excess activity of GC here could be contributing to the cognitive deficits associated with chronic stress (Mirescu and Gould, 2006; Jayatissa et al., 2008; Rainer et al., 2012; Du and Pang, 2015). The gene discussed is NR3C1; the disease is Cognitive impairment.