GRM2 and schizophrenia: An oral prodrug (LY2140023, pomaglumetad methionil) of an mGluR2/3 agonist (LY404039) had significant antispychotic efficacy in schizophrenia patients (Patil et al., 2007) or in subgroups of schizophrenia patients (Kinon et al., 2015; Nisenbaum et al., 2016).