Likewise, inhibition of OGA with O-(2-acetamido-2-deoxy-D-glucopyranosylidene) amino-N-phenylcarbamate (PUGNAc) induces insulin resistance in 3T3-L1 and rat primary adipocytes by perturbing both insulin-signaling pathway and glucose absorption (17, 21). The gene discussed is INS; the disease is Insulin resistance.