Reciprocally, OGT silencing or inhibition increases phosphorylation of AMPK, decreases phosphorylation of mTOR downstream effectors 4E-BP1 and p70S6K, decreases HIF-1a, GLUT1, and LDHA expression and impairs glucose uptake and growth in breast cancer cell lines (53) (Figure 2). The gene discussed is MTOR; the disease is breast carcinoma.