MAPT and nervous system disorder: In addition, mutations in tau, which regulates MT assembly, are associated with axonal transport deficiencies and were found in patients with neurological disorders, including FTD (Hutton et al., 1998; Wolfe, 2009) Alterations in the structural organization and transport of NFs in CNS neurons have been associated with many neurological disorders including ALS (Al-Chalabi et al., 1999; Cairns et al., 2004; Omary, 2004).