It has been observed that hypoxia-induced upregulation of MMP2 and MMP9 in breast and colon cancer cells contributed to tumor cell invasion (140, 141) and a membrane-bound form of MMP—MT1-MMP (MMP-14) is also induced via hypoxia in breast and renal carcinoma cells (141). Here, MMP14 is linked to malignant colon neoplasm.