Tregs, on the other hand, are thought to exert an immunosuppressive influence within the tumor microenvironment and are able to induce apoptosis of NK cells via direct cell-to-cell contact as well as through TGF-β secretion (118), but under some circumstances may promote tumor angiogenesis via the production of VEGFA, as has been demonstrated in an ovarian cancer murine xenograft model (119). Here, TGFB1 is linked to neoplasm.