Even though identification of variants using exome sequencing did not identify a causal variant, this region contains several plausible candidate genes which are highly expressed in relevant tissues (Ramsey et al., 2010), including IFNAR1, DYRK1A, SON, IFNGR2, MORC3, MRPS6, IL10RB, TMEM50B, CBR1, RCAN1, and TTC3. DYRK1A signaling pathway is linked to homocysteine cycle which is associated with an increased risk of atherosclerosis (Noll et al., 2009; Tlili et al., 2013). The gene discussed is TMEM50B; the disease is atherosclerosis.