The linkage peak at chromosome 21 harbors several genes that are highly expressed in tissues relevant for atherosclerosis (e.g., vascular, liver, kidney, gastrointestinal, and adipose tissue; Ramsey et al., 2010), including IFNAR1, DYRK1A, SON, IFNGR2, MORC3, MRPS6, IL10RB, TMEM50B, CBR1, RCAN1, and TTC3 (Figure 2). Here, TMEM50B is linked to atherosclerosis.