In MMTV-PyMT mammary carcinomas and RIP1-Tag2 pancreatic insulinomas, an Ang-2 neutralizing antibody administration did not reduce the recruitment of Tie-2+ TAMs but instead, prevented their binding to Ang-2 on activated endothelial cells subsequently decreasing angiogenesis and tumor progression (Mazzieri et al., 2011). Here, ANGPT2 is linked to breast carcinoma.