IGF2 and breast neoplasm: We recently showed that TAMs and CAFs are the main sources of Insulin-like growth factors 1 and 2 (IGF-1, IGF-2) in pancreatic and breast tumors, and that IGF signaling mediates resistance of murine pancreatic and breast tumors to gemcitabine and paclitaxel (Figure 3G) (Ireland et al., 2016, 2018).