INS and type 2 diabetes mellitus: Management of type 2 diabetes normally entails lifestyle modification (diet and exercise) as well as treatment with oral hypoglycemic drugs, such as insulin secretagogues (e.g., glimepiride) to stimulate insulin secretion, biguanides (e.g., metformin) to decrease hepatic glucose output, thiazolidinediones (e.g., rosiglitazone) to improve insulin sensitivity, and alpha-glucosidase inhibitors (e.g., acarbose) to reduce starch and sucrose digestion [3].