In a MACS cohort substudy that included 493 HIV-infected and 250 HIV-uninfected men, adiponectin concentrations were lower among men with HIV after adjusting for traditional CVD risk factors (P < 0.0001), and lower adiponectin concentrations were associated with increased odds of coronary stenosis (P < 0.007) [15]. The gene discussed is ADIPOQ; the disease is coronary stenosis.