Moreover, 21 days of HSYA to the BLM-induced chronic pulmonary fibrosis rats resulted in fibrosis amelioration by decreasing collagen deposition, and mRNA expression of TGF-β1, α-SMA and Col I connective tissue growth factor (CTGF) as well as α-SMA level [80, 81]. This evidence concerns the gene CCN2 and fibrosis.