Also, HYSA could decrease levels of total cholesterol (TC), triglyceride (TG), and mRNA expressions of transforming growth factor β receptor I (TGFβ-R I), transforming growth factor β receptor (TGFβ-R II), mitogen-activated protein (MAP), ERK, MAP/ERK kinase kinase 3 (MEKK3), and MAP kinase kinase-5 (MEK5) as well as phosphorylation of ERK5 in the tetrachloride- (CCl4-) induced hepatic fibrosis rats [63, 64]. Here, MAP2K5 is linked to Hepatic fibrosis.