It is believed that in response to endotoxins such as lipopolysaccharide (LPS) produced by periodontal microorganisms, there is an augment in the production of proinflammatory cytokines, chemokines, reactive oxygen species (ROS), and C-reactive protein (CRP) that can alter lipid metabolism and insulin resistance, leading to hyperlipidemia and hyperglycemia [22]. This evidence concerns the gene CRP and Hyperglycemia.