The levels of a key marker for cardiac remodeling, MMP-9, and the concentration of polypeptide protein, TGFβ-1 was noted to be significantly elevated in MI+LEF patients, in comparison with the control and MI+NEF group (p<0.01), as shown in Fig 1A and Fig 1B. The gene discussed is TGFB1; the disease is myocardial infarction.