A Kaplan–Meier survival curve estimated that the patients with HCC who were positive for both H3K36me3 and HNF1β had the lowest 5-year survival rate and a marginally lower rate than patients with HCC who were positive for either H3K36me3 or HNF1β (P = 0.0530). Here, HNF1B is linked to hepatocellular carcinoma.